Asialoglycoprotein receptor 1

Asialoglycoprotein receptor 1 (ASGPR1), also known as hepatic lectin 1, is a protein that in humans is encoded by the ASGR1 gene. It is a C-type lectin and a major hepatocyte surface receptor for asialoglycoprotein.

Function

The asialoglycoprotein receptor 1 is a transmembrane protein found in the cell membrane of hepatocytes. It is involved in the endocytosis of glycoproteins by binding to the terminal galactose or N-acetylgalactosamine residues on the glycoproteins. This receptor is typically recognized by the presence of galactose-terminated glycoproteins, such as asialoglycoprotein.

Structure

ASGPR1 is a type II transmembrane protein and is composed of two subunits, H1 and H2. Both subunits are type II membrane proteins that contain a single carbohydrate recognition domain (CRD). The CRD is responsible for binding to the galactose and N-acetylgalactosamine residues on the glycoproteins.

Clinical significance

Mutations in the ASGR1 gene have been associated with an increased risk of coronary artery disease. Additionally, the receptor has been implicated in the pathogenesis of some liver diseases, including hepatitis B and hepatitis C.

See also

• Asialoglycoprotein receptor
• Hepatocyte
• Asialoglycoprotein
• Galactose
• N-acetylgalactosamine
• Coronary artery disease
• Hepatitis B
• Hepatitis C