Azepine

Azepine is a seven-membered heterocyclic compound containing one nitrogen atom. It is a parent structure for several classes of drugs that have central nervous system (CNS) activity.

Chemistry

Azepine is a saturated compound and is the basis for the azepane and azepine families of compounds. The azepine ring is a part of many natural and synthetic compounds. The azepine ring system is present in many drugs, including those in the benzodiazepine class.

Pharmacology

Azepine derivatives have been studied for their potential therapeutic uses. Some azepine derivatives have shown anticonvulsant activity, while others have been found to have antipsychotic properties.

Anticonvulsant Activity

Some azepine derivatives have been found to have anticonvulsant activity. These compounds may work by enhancing the activity of the gamma-aminobutyric acid (GABA) neurotransmitter, which inhibits the activity of the nervous system.

Antipsychotic Properties

Some azepine derivatives have been found to have antipsychotic properties. These compounds may work by blocking the activity of the dopamine neurotransmitter, which is thought to be overactive in certain types of psychosis.

Synthesis

Azepine can be synthesized through several methods, including the Diels-Alder reaction and the cycloaddition of dienes and alkynes.

See Also

• Benzodiazepine
• Anticonvulsant
• Antipsychotic
• Diels-Alder reaction
• Cycloaddition