BMP5

BMP5 or Bone Morphogenetic Protein 5 is a protein that in humans is encoded by the BMP5 gene. BMP5 is part of the Bone Morphogenetic Protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues.

Function

The biological activity of BMP5 is thought to be mediated by the formation of heteromeric complexes of two different types of serine/threonine kinase receptors. The BMPs are involved in a host of cellular functions including cell growth, apoptosis, differentiation, migration, and immune response.

Clinical Significance

BMP5 has been implicated in a variety of diseases and conditions. It has been associated with osteogenesis imperfecta, a condition characterized by brittle bones that break easily. Additionally, BMP5 has been linked to osteoarthritis, a degenerative joint disease. BMP5 is also involved in the development and maintenance of the skeletal system, and alterations in its expression or function can lead to skeletal abnormalities.

Research

Research into BMP5 has focused on its role in bone and cartilage development and its potential use in regenerative medicine. Studies have shown that BMP5 can promote the differentiation of stem cells into bone and cartilage cells, suggesting it could be used to enhance bone healing and cartilage repair.

See Also

• Bone Morphogenetic Protein
• TGF-beta
• Osteogenesis Imperfecta
• Osteoarthritis

References

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