Delafloxacin meglumine

Delafloxacin Meglumine is an antibiotic used in the treatment of bacterial infections. It belongs to the class of fluoroquinolones, a group of broad-spectrum antibiotics that are effective against both Gram-positive and Gram-negative bacteria.

Mechanism of Action

Delafloxacin meglumine works by inhibiting the DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This inhibition results in the death of the bacteria, effectively treating the infection.

Uses

Delafloxacin meglumine is primarily used to treat acute bacterial skin and skin structure infections (ABSSSI) caused by certain susceptible bacteria, including Staphylococcus aureus, Streptococcus pyogenes, and Escherichia coli. It is also used in the treatment of community-acquired bacterial pneumonia (CABP).

Side Effects

Common side effects of delafloxacin meglumine include nausea, diarrhea, and headache. Serious side effects may include tendon rupture, nerve damage, and hypersensitivity reactions.

Contraindications

Delafloxacin meglumine is contraindicated in patients with a history of hypersensitivity to delafloxacin, other fluoroquinolones, or any components of the formulation. It is also contraindicated in patients with a history of tendon disorders related to fluoroquinolone administration.

Drug Interactions

Delafloxacin meglumine may interact with other drugs, including antacids, multivitamins, and didanosine, which can decrease its absorption and reduce its effectiveness.

Dosage

The dosage of delafloxacin meglumine varies depending on the type and severity of the infection, patient's age, weight, and kidney function.

See Also

• Fluoroquinolones
• Antibiotics
• Bacterial infections