Brophebarbital

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Brophebarbital is a barbiturate derivative. It has sedative and hypnotic properties, and was used in the mid- to late 20th century for the treatment of insomnia before being replaced by newer drugs with improved safety profiles.

History[edit | edit source]

Brophebarbital was first synthesized in the 1920s by the pharmaceutical company Hoffmann-La Roche. It was marketed under the brand name Nembutal and was widely used for its sedative and hypnotic effects. However, due to its potential for abuse and the development of tolerance, it fell out of favor and was largely replaced by newer, safer drugs in the 1960s and 1970s.

Pharmacology[edit | edit source]

Like other barbiturates, brophebarbital works by enhancing the action of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter, meaning it reduces the activity of the neurons to which it binds. Barbiturates enhance the effect of GABA, leading to sedation, relaxation, and sleep.

Side effects[edit | edit source]

Common side effects of brophebarbital include drowsiness, dizziness, and confusion. More serious side effects can include respiratory depression, dependence, and withdrawal symptoms upon discontinuation.

See also[edit | edit source]

References[edit | edit source]


Brophebarbital Resources

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Contributors: Prab R. Tumpati, MD