CD25 deficiency
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
CD25 deficiency | |
---|---|
![]() | |
Synonyms | IL2RA deficiency, Interleukin-2 receptor alpha chain deficiency |
Pronounce | N/A |
Specialty | N/A |
Symptoms | Recurrent infections, autoimmunity, lymphoproliferation |
Complications | Severe combined immunodeficiency (SCID) |
Onset | Infancy |
Duration | Lifelong |
Types | N/A |
Causes | Mutations in the IL2RA gene |
Risks | Family history of the condition |
Diagnosis | Genetic testing, flow cytometry |
Differential diagnosis | Other forms of SCID, X-linked severe combined immunodeficiency |
Prevention | N/A |
Treatment | Hematopoietic stem cell transplantation |
Medication | N/A |
Prognosis | Variable, depends on treatment |
Frequency | Rare |
Deaths | N/A |
Introduction[edit | edit source]
CD25 deficiency is a rare autosomal recessive immunodeficiency disorder characterized by the absence or dysfunction of the interleukin-2 receptor alpha chain (IL-2R_), also known as CD25. This condition leads to impaired immune system function, resulting in increased susceptibility to infections and autoimmune disorders.
Pathophysiology[edit | edit source]
CD25 is a component of the high-affinity interleukin-2 receptor complex, which is crucial for the proliferation and survival of T cells. In CD25 deficiency, the lack of functional IL-2R_ impairs the signaling pathways necessary for T cell activation and regulatory T cell (Treg) development. This results in a compromised immune response and a failure to maintain immune tolerance, leading to autoimmunity.
Clinical Presentation[edit | edit source]
Patients with CD25 deficiency typically present in early childhood with recurrent infections, lymphadenopathy, and failure to thrive. Autoimmune manifestations may include autoimmune hemolytic anemia, immune thrombocytopenic purpura, and type 1 diabetes mellitus.
Diagnosis[edit | edit source]
The diagnosis of CD25 deficiency is based on clinical evaluation, laboratory findings, and genetic testing. Laboratory tests often reveal low or absent CD25 expression on T cells, reduced Treg numbers, and impaired T cell proliferation in response to IL-2. Genetic testing can confirm mutations in the IL2RA gene, which encodes the IL-2R_ chain.
Treatment[edit | edit source]
Management of CD25 deficiency involves supportive care, including prophylactic antibiotics to prevent infections and immunosuppressive therapy to control autoimmune symptoms. Hematopoietic stem cell transplantation (HSCT) may be considered in severe cases to restore immune function.
Prognosis[edit | edit source]
The prognosis for individuals with CD25 deficiency varies depending on the severity of the condition and the success of treatment interventions. Early diagnosis and appropriate management can improve outcomes and quality of life.
See also[edit | edit source]
Transform your life with W8MD's budget GLP1 injections from $125
W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.
Why choose W8MD?
- Comprehensive care with FDA-approved weight loss medications including:
- loss injections in NYC both generic and brand names:
- weight loss medications including Phentermine, Qsymia, Diethylpropion etc.
- Accept most insurances for visits or discounted self pay cost.
- Generic weight loss injections starting from just $125.00 for the starting dose
- In person weight loss NYC and telemedicine medical weight loss options in New York city available
- Budget GLP1 weight loss injections in NYC starting from $125.00 biweekly with insurance!
Book Your Appointment
Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD