CD300A

CD300A is a protein that in humans is encoded by the CD300A gene. It is also known as IRp60, CMRF-35-like molecule 8 or CLM-8. The CD300A protein is a member of the CD300 molecule family, which is a group of proteins that play important roles in the immune system.

Function

The CD300A protein is an inhibitory receptor that is expressed on the surface of various immune cells, including natural killer cells, monocytes, and T cells. It plays a crucial role in regulating the immune response by inhibiting the activation of these cells.

Structure

The CD300A protein is a type I transmembrane protein that consists of a single immunoglobulin domain, a transmembrane domain, and a cytoplasmic domain. The cytoplasmic domain contains two immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which are responsible for the inhibitory function of the protein.

Clinical significance

Alterations in the expression or function of CD300A have been associated with various diseases, including autoimmune diseases, cancer, and infectious diseases. For example, increased expression of CD300A has been observed in leukemia cells, suggesting that it may play a role in the development of this type of cancer.

Research

Research is ongoing to further understand the role of CD300A in the immune system and its potential as a target for therapeutic interventions. For example, studies are investigating the possibility of using CD300A as a marker for certain types of immune cells or as a target for immunotherapy in cancer treatment.

See also

• CD300
• Immunoglobulin superfamily
• Immunoreceptor tyrosine-based inhibitory motif