CD48

CD48 is a protein that in humans is encoded by the CD48 gene. It is a member of the SLAM family of immunological transmembrane proteins, and functions as a high-affinity ligand for the natural killer cell inhibitory receptor CD244.

Structure

The CD48 protein is a glycoprotein that exists on the surface of lymphocytes and other immune cells, platelets, and endothelial cells. It is anchored to the cell membrane through a glycosylphosphatidylinositol (GPI) link. The protein is approximately 45 kDa in size and is composed of an extracellular domain, a transmembrane domain, and a short cytoplasmic tail.

Function

CD48 plays a crucial role in the immune response and the regulation of immune cell activation. It interacts with CD2 to regulate T cell activation and cytokine production. CD48 also binds to CD244 on natural killer cells, modulating their activity in response to pathogens and tumor cells.

Clinical significance

Alterations in CD48 expression or function have been associated with various diseases. Overexpression of CD48 has been observed in certain types of cancer, including leukemia and lymphoma, and is associated with poor prognosis. CD48 is also implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it is thought to contribute to the inappropriate activation of the immune system.

Research

CD48 is a target of interest in the development of immunotherapy treatments for cancer and autoimmune diseases. Inhibitors of CD48 are being investigated for their potential to modulate the immune response and improve patient outcomes.

See also

• Cluster of differentiation
• Immunology
• Natural killer cell
• Autoimmune disease
• Cancer immunotherapy

References

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