CDH3 (gene)
CDH3 is a gene that encodes for the protein P-cadherin, a type of cadherin. Cadherins are a class of type-1 transmembrane proteins that play crucial roles in cell adhesion, ensuring that cells within tissues are bound together. They are dependent on calcium (Ca2+) ions to function, hence their name.
Structure[edit | edit source]
The CDH3 gene is located on the long (q) arm of chromosome 16 at position 22.1. The gene spans approximately 27 kilobases and contains 16 exons. The encoded protein, P-cadherin, is 829 amino acids long with a predicted molecular weight of approximately 90 kDa.
Function[edit | edit source]
P-cadherin is a classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays a role in the establishment and maintenance of epithelial cell-cell adhesion, cell polarity and tissue architecture. In addition, P-cadherin is thought to play a role in tumor suppression.
Clinical significance[edit | edit source]
Mutations in the CDH3 gene have been associated with several diseases, including hypotrichosis with juvenile macular dystrophy, ectodermal dysplasia, and congenital hypotrichosis with juvenile macular dystrophy.
See also[edit | edit source]
References[edit | edit source]
Template:Genes on human chromosome 16
Template:Cell adhesion proteins
Translate: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD