CENPF

An overview of the CENPF gene and its role in cell division

CENPF (Centromere Protein F) is a gene that encodes a protein involved in cell division, specifically during the mitotic phase of the cell cycle. CENPF is a crucial component of the kinetochore, a complex structure that assembles on the centromere of each chromosome during cell division. This protein plays a significant role in ensuring proper chromosome alignment and segregation, which is vital for maintaining genomic stability.

Function

CENPF is a large protein that localizes to the kinetochore during the G2 phase of the cell cycle and remains associated with the kinetochore until the anaphase of mitosis. It is involved in the attachment of microtubules to the kinetochore, facilitating the movement of chromosomes during cell division. CENPF interacts with other kinetochore proteins and is essential for the proper functioning of the spindle assembly checkpoint, a safety mechanism that ensures chromosomes are correctly aligned before the cell proceeds to anaphase.

Clinical Significance

Mutations or dysregulation of the CENPF gene have been associated with various cancers, as improper chromosome segregation can lead to aneuploidy, a condition characterized by an abnormal number of chromosomes. Studies have shown that overexpression of CENPF is linked to poor prognosis in certain types of cancer, including breast cancer and prostate cancer.

Research and Studies

Research on CENPF has provided insights into its role in oncogenesis and its potential as a biomarker for cancer diagnosis and prognosis. Ongoing studies are exploring the possibility of targeting CENPF in cancer therapy, aiming to disrupt its function in cancer cells to inhibit their proliferation.

Also see

• Kinetochore
• Mitosis
• Centromere
• Spindle assembly checkpoint
• Chromosome segregation