CLIC4

CLIC4 (Chloride Intracellular Channel 4) is a protein that in humans is encoded by the CLIC4 gene. It is a member of the chloride intracellular channel (CLIC) family of proteins. CLIC4 is involved in multiple cellular processes and has been implicated in various diseases, including cancer and skin disorders.

Function

CLIC4 is a member of the chloride intracellular channel (CLIC) family of proteins. These proteins are known to have diverse functions, including chloride ion transport, cell volume regulation, and cell cycle control. CLIC4 is thought to function primarily in endosomal trafficking and apoptotic volume decrease.

Structure

The CLIC4 protein has a unique structure that allows it to exist in both a soluble, cytoplasmic form and a membrane-bound form. This dual state is thought to be important for its function in endosomal trafficking.

Clinical significance

Alterations in the expression of CLIC4 have been associated with a variety of diseases. For example, increased expression of CLIC4 has been observed in several types of cancer, including breast cancer, lung cancer, and pancreatic cancer. In contrast, decreased expression of CLIC4 has been linked to certain skin disorders, such as psoriasis and atopic dermatitis.

Research

Research into the function and potential therapeutic applications of CLIC4 is ongoing. For example, studies are investigating the role of CLIC4 in cancer progression and its potential as a therapeutic target in cancer treatment.

See also

• Chloride channel
• Endosome
• Apoptosis