Carboxycyclophosphamide

Carboxycyclophosphamide is a metabolite of the chemotherapy drug cyclophosphamide. It is formed in the body after administration of cyclophosphamide, through the process of metabolism.

Chemistry

Carboxycyclophosphamide is a phosphoramide compound, which means it contains a phosphorus atom bonded to an amide group. Its chemical formula is C7H15Cl2N2O5P, and its molecular weight is 307.08 g/mol.

Pharmacology

Carboxycyclophosphamide is one of the inactive metabolites of cyclophosphamide. It is formed in the liver by the action of cytochrome P450 enzymes, specifically CYP2B6 and CYP3A4/5. The formation of carboxycyclophosphamide is part of the detoxification process of cyclophosphamide in the body.

Clinical significance

Although carboxycyclophosphamide itself is not active as a chemotherapy drug, its formation is an important part of the body's response to cyclophosphamide treatment. The levels of carboxycyclophosphamide in the body can be used as a marker of cyclophosphamide metabolism, and may help to predict individual patient's response to the drug.

See also

• Cyclophosphamide
• Metabolism
• Chemotherapy

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