Celsior

Celsior is a preservation solution used in the field of organ transplantation. It is designed to maintain the viability of organs outside the body, particularly during the period between organ retrieval and transplantation. Celsior is known for its effectiveness in preserving a variety of organs, including the heart, lungs, liver, kidneys, and pancreas.

Composition

Celsior solution contains a mixture of electrolytes, buffers, and other components that help to protect the organ tissues from damage during the preservation period. The key components include:

• Histidine
• Mannitol
• Lactobionic acid
• Glutathione
• Calcium chloride
• Magnesium chloride
• Potassium chloride
• Sodium chloride

Mechanism of Action

The solution works by reducing cellular metabolism and preventing the accumulation of harmful substances that can lead to cell damage. It helps to maintain the structural integrity of cell membranes and reduces oxidative stress, which is crucial for the preservation of organ function.

Applications

Celsior is used in various types of organ transplants, including:

• Heart transplantation
• Lung transplantation
• Liver transplantation
• Kidney transplantation
• Pancreas transplantation

Advantages

Celsior offers several advantages over other preservation solutions:

• It provides excellent protection against ischemia-reperfusion injury.
• It is suitable for multiple types of organs.
• It has a longer preservation time compared to some other solutions.

Related Pages

• Organ transplantation
• Heart transplantation
• Lung transplantation
• Liver transplantation
• Kidney transplantation
• Pancreas transplantation
• Ischemia-reperfusion injury
• Organ preservation

See Also

• University of Wisconsin solution
• Histidine-tryptophan-ketoglutarate solution