Chlormadinone

Chemical structure of Chlormadinone

Chlormadinone is a synthetic progestin that is used in various hormonal therapies. It is a derivative of progesterone and is known for its anti-androgenic properties. Chlormadinone is often used in combination with estrogens in oral contraceptives and in the treatment of menstrual disorders.

Pharmacology

Chlormadinone acts primarily as a progestogen, binding to the progesterone receptor and exerting effects similar to those of natural progesterone. It also has anti-androgenic activity, which makes it useful in conditions like hirsutism and acne.

Mechanism of Action

Chlormadinone works by inhibiting the secretion of gonadotropins from the pituitary gland, which in turn suppresses ovulation. Its anti-androgenic effects are due to its ability to block androgen receptors, reducing the effects of testosterone and other androgens.

Clinical Uses

Chlormadinone is used in several clinical settings:

• As a component of combined oral contraceptive pills to prevent pregnancy.
• In the treatment of dysmenorrhea, menorrhagia, and other menstrual disorders.
• For the management of androgen-dependent conditions such as acne and hirsutism.

Side Effects

Common side effects of chlormadinone include:

• Nausea
• Headache
• Breast tenderness
• Weight gain

Serious side effects can include an increased risk of thrombosis and cardiovascular events, particularly in smokers and women over 35.

Related pages

• Progestin
• Oral contraceptive
• Menstrual disorder
• Anti-androgen