Chlorozotocin
A glucose-linked chloroethylnitrosourea with potential antineoplastic activity.
Mechanism of action[edit | edit source]
Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death.
Potential use[edit | edit source]
- This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models.
- Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas.
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