Clorprenaline
Overview of the drug Clorprenaline
| Clorprenaline | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Clorprenaline is a beta-adrenergic agonist used primarily in the treatment of asthma and other conditions involving bronchospasm. It functions by stimulating beta-2 adrenergic receptors, leading to the relaxation of bronchial smooth muscle.
Pharmacology[edit | edit source]
Clorprenaline is a selective beta-2 adrenergic receptor agonist. By binding to these receptors, it activates the adenylate cyclase pathway, increasing the levels of cyclic adenosine monophosphate (cAMP) within the cells. This biochemical cascade results in the relaxation of smooth muscle in the airways, leading to bronchodilation and improved airflow in patients with obstructive airway diseases.
Medical uses[edit | edit source]
Clorprenaline is primarily indicated for the management of asthma and chronic obstructive pulmonary disease (COPD). It is used to relieve symptoms such as wheezing, shortness of breath, and chest tightness.
Side effects[edit | edit source]
Common side effects of Clorprenaline include tremor, nervousness, and tachycardia. These effects are generally mild and result from the systemic activation of beta-adrenergic receptors. In some cases, patients may experience palpitations, headache, or dizziness.
Mechanism of action[edit | edit source]
Clorprenaline acts by mimicking the action of epinephrine on beta-2 adrenergic receptors. This leads to the activation of adenylate cyclase, which converts ATP to cAMP. The increase in cAMP levels causes the relaxation of bronchial smooth muscle, reducing airway resistance and facilitating breathing.
Administration[edit | edit source]
Clorprenaline is typically administered via inhalation, allowing for direct delivery to the lungs and minimizing systemic side effects. It can also be administered orally or via injection in certain clinical scenarios.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
