Cold autoimmune hemolytic anemia
Cold Autoimmune Hemolytic Anemia[edit | edit source]
Cold Autoimmune Hemolytic Anemia (CAHA) is a rare type of autoimmune hemolytic anemia (AIHA) characterized by the premature destruction of red blood cells (RBCs) at low temperatures. This condition is mediated by autoantibodies that bind to RBCs, leading to their destruction by the immune system.
Pathophysiology[edit | edit source]
In CAHA, the immune system produces cold agglutinins, which are antibodies that react with RBCs at temperatures below normal body temperature, typically between 0°C and 30°C. These antibodies are usually of the IgM class and can cause RBCs to clump together (agglutinate) and be destroyed, primarily in the liver and spleen.
Symptoms[edit | edit source]
The symptoms of CAHA can vary depending on the severity of the condition and the degree of hemolysis. Common symptoms include:
Diagnosis[edit | edit source]
Diagnosis of CAHA involves several laboratory tests, including:
- Complete blood count (CBC) showing anemia
- Direct Coombs test (direct antiglobulin test) positive for complement
- Detection of cold agglutinins in the blood
- Blood smear showing agglutinated RBCs
Treatment[edit | edit source]
Treatment of CAHA focuses on managing symptoms and preventing hemolysis. Strategies include:
- Avoiding exposure to cold temperatures
- Use of immunosuppressive drugs such as rituximab
- Plasmapheresis in severe cases
Prognosis[edit | edit source]
The prognosis for individuals with CAHA varies. Some patients may experience mild symptoms, while others may have severe anemia requiring medical intervention. The condition can be chronic, with periods of remission and exacerbation.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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