Lymphoproliferative disorders

Lymphoproliferative disorders are diseases characterized by the abnormal proliferation of lymphocytes, a type of white blood cell. These disorders can be benign or malignant and can affect both children and adults. They are often associated with immune system dysfunction.

Types of Lymphoproliferative Disorders

There are several types of lymphoproliferative disorders, including:

• Chronic lymphocytic leukemia (CLL)
• Non-Hodgkin lymphoma (NHL)
• Hodgkin lymphoma (HL)
• Multiple myeloma (MM)
• Waldenström macroglobulinemia (WM)

Causes

The exact cause of lymphoproliferative disorders is unknown, but they are often associated with immune system dysfunction. Some disorders are linked to specific genetic mutations, while others may be triggered by infections or exposure to certain chemicals or radiation.

Symptoms

Symptoms of lymphoproliferative disorders can vary widely depending on the specific disorder and the individual patient. Common symptoms may include:

• Fatigue
• Fever
• Night sweats
• Weight loss
• Swollen lymph nodes

Diagnosis

Diagnosis of lymphoproliferative disorders typically involves a combination of physical examination, medical history, laboratory tests, and imaging studies. A biopsy of affected tissue may also be performed.

Treatment

Treatment for lymphoproliferative disorders depends on the specific disorder and the patient's overall health. Options may include chemotherapy, radiation therapy, immunotherapy, targeted therapy, stem cell transplant, or a combination of these.

See Also

• Leukemia
• Lymphoma
• Myeloma
• Waldenström macroglobulinemia

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