Corticotropin releasing hormone

Corticotropin-releasing hormone (CRH), also known as corticotropin-releasing factor (CRF), is a peptide hormone and neurotransmitter involved in the stress response. It is a primary hormone responsible for the body's reaction to stress, and has been associated with the onset of anxiety and depression when present in high levels.

Function

CRH is produced in the hypothalamus, a region of the brain responsible for linking the nervous system to the endocrine system via the pituitary gland. It is released in response to stress, and triggers a series of reactions in the body to prepare it for a 'fight or flight' response. This includes the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn stimulates the release of cortisol from the adrenal glands.

Role in Disease

High levels of CRH have been associated with several stress-related disorders, including major depressive disorder, post-traumatic stress disorder (PTSD), and anxiety disorders. It is thought that the overproduction of CRH can lead to an overactive stress response, resulting in the symptoms associated with these disorders.

Therapeutic Potential

Due to its role in stress-related disorders, CRH is a potential target for therapeutic intervention. Several drugs that block the CRH receptor have been developed and are currently being tested in clinical trials. These include antagonists that block the CRH receptor, preventing the hormone from triggering the stress response.

See Also

• Hypothalamic–pituitary–adrenal axis
• Stress (biology)
• Cortisol