Cryofibrinogenemic purpura

From WikiMD's Wellnesspedia

Cryofibrinogenemic purpura is a rare medical condition characterized by the presence of cryofibrinogens in the blood, leading to purpura, or purple-colored spots and patches on the skin. This condition is often associated with cold exposure and can cause a variety of symptoms, including skin lesions, joint pain, and in severe cases, organ damage.

Symptoms and Signs[edit | edit source]

The primary symptom of cryofibrinogenemic purpura is the appearance of purpura, or purple-colored spots and patches, on the skin. These lesions are often painful and can occur anywhere on the body, but are most commonly found on the legs. Other symptoms can include joint pain, fatigue, and in severe cases, organ damage.

Causes[edit | edit source]

Cryofibrinogenemic purpura is caused by the presence of cryofibrinogens in the blood. Cryofibrinogens are abnormal proteins that become insoluble at low temperatures, leading to the formation of clots in the small blood vessels of the skin. The exact cause of cryofibrinogen production is unknown, but it is often associated with underlying conditions such as cancer, autoimmune diseases, and infections.

Diagnosis[edit | edit source]

Diagnosis of cryofibrinogenemic purpura is based on the presence of cryofibrinogens in the blood, which can be detected through a blood test. Skin biopsy may also be performed to confirm the diagnosis.

Treatment[edit | edit source]

Treatment for cryofibrinogenemic purpura is primarily aimed at managing symptoms and preventing complications. This can include avoiding cold exposure, using warm compresses on affected areas, and taking medications to reduce inflammation and prevent clot formation. In severe cases, plasmapheresis may be performed to remove cryofibrinogens from the blood.

See Also[edit | edit source]

References[edit | edit source]


Cryofibrinogenemic purpura Resources

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Contributors: Prab R. Tumpati, MD