Cutaneous B-cell lymphoma

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Cutaneous B-cell lymphoma
Cutaneous B-cell lymphoma
Synonyms N/A
Pronounce N/A
Specialty N/A
Symptoms Skin lesions, nodules, plaques
Complications Secondary infection, systemic spread
Onset Variable
Duration Chronic
Types N/A
Causes B-cell proliferation
Risks Immunosuppression, genetic predisposition
Diagnosis Biopsy, immunohistochemistry
Differential diagnosis Cutaneous T-cell lymphoma, dermatitis, psoriasis
Prevention N/A
Treatment Radiation therapy, chemotherapy, immunotherapy
Medication N/A
Prognosis Variable, depends on subtype
Frequency Rare
Deaths N/A


Cutaneous B-cell lymphoma (CBCL) is a type of non-Hodgkin lymphoma that primarily affects the skin. It is a rare condition, accounting for less than 5% of all cases of cutaneous lymphomas. CBCL is characterized by the presence of B-cell lymphocytes in the skin, which are a type of white blood cell that produces antibodies to fight infections.

Types[edit | edit source]

There are three main types of CBCL: primary cutaneous marginal zone B-cell lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type.

Symptoms[edit | edit source]

The symptoms of CBCL can vary depending on the type and stage of the disease. Common symptoms include skin lesions that may be red, purple, or brown and may appear as patches, plaques, or nodules. Some people may experience itching, pain, or discomfort in the affected area.

Diagnosis[edit | edit source]

Diagnosis of CBCL typically involves a skin biopsy, where a small sample of the affected skin is removed and examined under a microscope. Additional tests, such as blood tests, imaging studies, and bone marrow biopsy, may be performed to determine the extent of the disease.

Treatment[edit | edit source]

Treatment for CBCL depends on the type and stage of the disease, as well as the patient's overall health. Options may include radiotherapy, chemotherapy, immunotherapy, and targeted therapy. In some cases, a skin-directed therapy such as topical corticosteroids, retinoids, or phototherapy may be used.

Prognosis[edit | edit source]

The prognosis for CBCL varies depending on the type and stage of the disease. In general, the prognosis is good for primary cutaneous marginal zone B-cell lymphoma and primary cutaneous follicle center lymphoma, with a high rate of long-term survival. The prognosis for primary cutaneous diffuse large B-cell lymphoma, leg type, is less favorable, but improvements in treatment have led to better survival rates in recent years.

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Contributors: Prab R. Tumpati, MD