Cyclic citrullinated peptide

Cyclic citrullinated peptide antibodies, or CCP antibodies, are a type of antibody called autoantibodies.

Rheumatoid arthritis

What are autoantibodies?

Antibodies and autoantibodies are proteins made by the immune system.

CCP antibody test

CCP antibodies target healthy tissues in the joints and hence presence of CCP antibodies can be a sign of rheumatoid arthritis.

Other names

Cyclic citrullinated peptide antibody, anticitrullinated peptide antibody, citrulline antibody, anti-cyclic citrullinated peptide, anti-CCP antibody, ACPA

Other tests

Another test that is commonly performed in the diagnostic evaluation of rheumatoid arthritis is rheumatoid factor (RF) test as well as a physical exam

Interpreting CCP test rests

CCP test results are interpreted along with RF test and clinical presentation.

• Positive CCP antibodies and positive RF, it likely means that you have rheumatoid arthritis.
• Positive CCP antibodies and negative RF, it may mean you are in the early stages of rheumatoid arthritis or will develop it in the future.
• Negative CCP antibodies and negative RF, it means you are less likely to have rheumatoid arthritis.

Cyclic citrullinated peptide Resources
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