Anti-histone antibodies

Anti-histone antibodies are a type of autoantibody that are frequently found in the blood of people with autoimmune diseases, such as systemic lupus erythematosus (SLE). They are directed against histones, which are proteins that help to package DNA within the nucleus of a cell.

Overview

Anti-histone antibodies are found in almost all cases of drug-induced lupus, a syndrome that is similar to SLE. They are also found in about half of people with SLE and in lower percentages of people with other autoimmune diseases.

Role in Autoimmune Diseases

The presence of anti-histone antibodies in the blood is a strong indicator of an autoimmune disease. However, the exact role these antibodies play in the development and progression of these diseases is not fully understood. It is believed that they may contribute to the inflammation and tissue damage that occurs in these conditions.

Testing for Anti-Histone Antibodies

Testing for anti-histone antibodies is typically done using a blood test. This test is often used to help diagnose SLE and drug-induced lupus, and to distinguish these conditions from other autoimmune diseases.

Treatment

Treatment for conditions associated with anti-histone antibodies typically involves managing the underlying autoimmune disease. This may include medications to reduce inflammation and suppress the immune system, as well as lifestyle changes to manage symptoms.

See Also

• Autoantibody
• Systemic lupus erythematosus
• Drug-induced lupus
• Histones

References

Anti-histone antibodies Resources
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