Autoimmune polyendocrine syndrome

From WikiMD's Wellnesspedia

Autoimmune polyendocrine syndrome (APS), also known as polyglandular autoimmune syndrome (PGAS), is a group of rare, heterogeneous, and inherited disorders characterized by the malfunction of the immune system, leading to the attack of more than one endocrine organ.

Overview[edit | edit source]

APS is classified into three types: APS-1, APS-2, and APS-3. Each type is distinguished by the presence of two or more specific diseases. APS-1, also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED), is a rare inherited disorder. APS-2, also known as Schmidt's syndrome, is less rare and occurs in adults. APS-3 is characterized by the presence of autoimmune thyroid disease (AITD) and another autoimmune disease.

Symptoms[edit | edit source]

The symptoms of APS vary depending on the glands affected by the disorder. Common symptoms include fatigue, stomach upset, low blood pressure, weight loss, excessive thirst and urination, and skin changes. The symptoms can worsen over time, especially if left untreated.

Causes[edit | edit source]

APS is caused by a problem with the immune system. Normally, the immune system protects the body from harmful substances like bacteria and viruses. But in APS, the immune system mistakenly attacks the body's own tissues and organs.

Diagnosis[edit | edit source]

Diagnosis of APS is based on the presence of at least two characteristic diseases. Blood tests can be used to confirm the diagnosis and to determine which glands are affected.

Treatment[edit | edit source]

Treatment for APS focuses on managing the symptoms and treating the underlying autoimmune diseases. This may include hormone replacement therapy, medications to suppress the immune system, and lifestyle changes.

See also[edit | edit source]

References[edit | edit source]


Autoimmune polyendocrine syndrome Resources

Find a healthcare provider anywhere in the world quickly and easily!

Wiki.png

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD


Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.


Contributors: Admin, Prab R. Tumpati, MD