Vindesine

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Vindesin.svg

Vindesine is a chemotherapy medication used in the treatment of various types of cancer. It belongs to the class of drugs known as vinca alkaloids, which are derived from the periwinkle plant Catharanthus roseus. Vindesine works by inhibiting the growth of cancer cells by interfering with the formation of microtubules, which are essential for cell division.

Medical Uses[edit | edit source]

Vindesine is primarily used in the treatment of:

Mechanism of Action[edit | edit source]

Vindesine exerts its anti-cancer effects by binding to tubulin, a protein that is a key component of microtubules. By binding to tubulin, vindesine prevents the polymerization of microtubules, which is essential for mitosis (cell division). This disruption of microtubule formation leads to cell cycle arrest and ultimately, cell death.

Side Effects[edit | edit source]

Common side effects of vindesine include:

Administration[edit | edit source]

Vindesine is administered intravenously, typically in a hospital or clinical setting. The dosage and schedule depend on the type of cancer being treated, the patient's overall health, and other factors.

History[edit | edit source]

Vindesine was first synthesized in the 1970s as a semi-synthetic derivative of vinblastine, another vinca alkaloid. It was developed to improve the therapeutic index and reduce the side effects associated with vinblastine.

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]


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Contributors: Prab R. Tumpati, MD