DBX2

DBX2 is a gene that in humans is encoded by the DBX2 protein. This gene is a member of the developing brain homeobox (DBX) family, which plays a crucial role in the formation of neuronal circuits in the developing brain.

Function

DBX2 is a transcription factor that is involved in the development of the central nervous system. It is expressed in the neural tube and is involved in the specification of neuronal cell types. DBX2 is also involved in the regulation of neurogenesis, the process by which neurons are generated from neural stem and progenitor cells.

Clinical significance

Mutations in the DBX2 gene have been associated with a variety of neurological disorders, including autism, schizophrenia, and intellectual disability. Further research is needed to fully understand the role of DBX2 in these conditions.

Research

Research on DBX2 has focused on its role in the development of the central nervous system and its potential involvement in neurological disorders. Studies have shown that DBX2 is crucial for the formation of specific neuronal circuits in the brain, and that alterations in its expression can lead to abnormalities in brain development.

See also

• Homeobox
• Neurogenesis
• Transcription factor