DU-145

DU-145 is a cell line derived from a brain metastasis of a human prostate cancer patient. It is commonly used in cancer research to study the biology and treatment of prostate cancer.

History

The DU-145 cell line was established in 1978 from a metastatic lesion of a 69-year-old Caucasian male. The cells were derived from a brain metastasis, which is a common site of prostate cancer spread. The cell line has been used extensively in research since its establishment.

Characteristics

DU-145 cells are epithelial in nature and grow in a monolayer. They are androgen-independent, meaning they can grow without the presence of male hormones. This makes them a useful model for studying advanced stages of prostate cancer, which often become androgen-independent.

The cells have a doubling time of approximately 30-40 hours and are resistant to many chemotherapeutic agents. They also express a number of oncogenes and tumor suppressor genes, including p53 and Rb.

Use in Research

DU-145 cells are used in a variety of research applications. They are often used to study the effects of new drugs or treatments on prostate cancer cells. They can also be used to study the genetic and molecular changes that occur in prostate cancer.

In addition, DU-145 cells are often used in in vitro and in vivo experiments to study the biology of prostate cancer. This includes studies on cell growth, migration, invasion, and apoptosis.

See Also

• PC-3
• LNCaP
• Prostate cancer

References

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