Deramciclane

Deramciclane is an anxiolytic drug that belongs to the class of cyclohexane derivatives. It is primarily used for the treatment of anxiety disorders. Deramciclane functions by modulating the activity of the gamma-aminobutyric acid (GABA) system in the central nervous system.

Mechanism of Action

Deramciclane acts as a serotonin receptor antagonist, particularly at the 5-HT2A and 5-HT2C receptors. This action helps to reduce anxiety by inhibiting the overactivity of these receptors, which is often associated with anxiety and stress.

Pharmacokinetics

The drug is administered orally and has a high bioavailability. It is metabolized in the liver and has a relatively long elimination half-life, which allows for once-daily dosing. The metabolites are excreted primarily through the urine.

Clinical Use

Deramciclane is used in the management of various anxiety disorders, including generalized anxiety disorder (GAD) and panic disorder. It has been shown to be effective in reducing the symptoms of anxiety with a favorable side effect profile compared to other anxiolytics such as benzodiazepines.

Side Effects

Common side effects of Deramciclane include drowsiness, dizziness, and dry mouth. Less common but more severe side effects can include hypotension and tachycardia.

Contraindications

Deramciclane is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should be used with caution in patients with hepatic impairment due to its metabolism in the liver.

See Also

• Anxiolytic
• Serotonin receptor
• Generalized anxiety disorder
• Panic disorder