Didesmethylsibutramine

Didesmethylsibutramine is a pharmaceutical drug that is primarily used as an appetite suppressant. It is a metabolite of sibutramine, a drug that was previously used for the treatment of obesity but was withdrawn from the market due to associated health risks.

Pharmacology

Didesmethylsibutramine acts by inhibiting the reuptake of neurotransmitters such as serotonin, norepinephrine, and to a lesser extent, dopamine. This results in increased levels of these neurotransmitters in the synaptic cleft, which in turn suppresses appetite.

Clinical Use

Didesmethylsibutramine was never approved for use as a standalone drug. However, it is a primary metabolite of sibutramine, which was used for the treatment of obesity. Sibutramine was withdrawn from the market in many countries due to an increased risk of cardiovascular events and strokes.

Side Effects

The side effects of didesmethylsibutramine are similar to those of sibutramine. These can include dry mouth, insomnia, constipation, and increased heart rate. More serious side effects can include high blood pressure and an increased risk of cardiovascular events.

Regulation

Due to its association with sibutramine, didesmethylsibutramine is also regulated in many countries. It is often included in the list of substances that are tested for in anti-doping screenings.

See Also

• Sibutramine
• Appetite suppressant
• Obesity