Diffuse large b-cell lymphoma
a non-hodgkin lymphoma characterized by a diffuse proliferation of predominantly large neoplastic b lymphocytes. It is the most frequently seen type of non-hodgkin lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities include t-cell/histiocyte rich large b-cell lymphoma, primary diffuse large b-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary cutaneous diffuse large b-cell lymphoma, leg type, and alk-positive large b-cell lymphoma.
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Contributors: Prab R. Tumpati, MD
