Diprophylline

Diprophylline is a bronchodilator that is used in the treatment of asthma, chronic bronchitis, and emphysema. It belongs to the xanthine class of drugs, which also includes theophylline and aminophylline.

Mechanism of Action

Diprophylline works by relaxing the smooth muscle in the bronchial tubes and pulmonary arteries, thereby increasing airflow and improving lung function. It does this by inhibiting the enzyme phosphodiesterase, which breaks down cyclic AMP. Increased levels of cyclic AMP lead to relaxation of the smooth muscle.

Pharmacokinetics

After oral administration, diprophylline is rapidly absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted in the urine.

Side Effects

Common side effects of diprophylline include nausea, vomiting, abdominal pain, and headache. In rare cases, it can cause arrhythmia, seizures, and hypotension.

Contraindications

Diprophylline is contraindicated in patients with hypersensitivity to xanthines, and in those with peptic ulcer disease or seizure disorders.

Drug Interactions

Diprophylline may interact with other drugs, including cimetidine, erythromycin, and fluoroquinolones, which can increase its blood levels and risk of toxicity.

References

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