Disseminate and recurrent infundibulofolliculitis

Disseminate and Recurrent Infundibulofolliculitis (DARI) is a rare skin condition characterized by the chronic eruption of itchy, follicular papules. The condition primarily affects the trunk and extremities, sparing the face, palms, and soles. DARI is considered a disorder of the hair follicles, specifically the infundibular region of the follicle. The exact cause of DARI remains unknown, but it is thought to involve a combination of genetic and environmental factors. The condition is more commonly reported in individuals with darker skin and typically begins in young adulthood.

Symptoms and Diagnosis

The primary symptom of Disseminate and Recurrent Infundibulofolliculitis is the appearance of small, itchy, red or skin-colored papules on the trunk and limbs. These papules are closely associated with hair follicles. Patients may report mild to severe itching. Unlike many other skin conditions, DARI does not affect the face, palms, or soles.

Diagnosis of DARI is primarily clinical, based on the characteristic appearance and distribution of the lesions. Dermoscopy may aid in the diagnosis by revealing specific features associated with follicular papules. In some cases, a skin biopsy may be performed to rule out other conditions and to confirm the diagnosis. Histopathological examination typically shows a nonspecific perifollicular inflammatory infiltrate without significant epidermal changes.

Treatment

There is no definitive cure for Disseminate and Recurrent Infundibulofolliculitis, and treatment is aimed at managing symptoms. Topical corticosteroids and antipruritics may be used to reduce itching and inflammation. In some cases, phototherapy has been reported to be beneficial. The use of systemic medications, such as antibiotics or isotretinoin, has been described in the literature but with variable success. Management of DARI often requires a trial and error approach to identify the most effective treatment for individual patients.

Epidemiology

The exact prevalence of Disseminate and Recurrent Infundibulofolliculitis is unknown due to its rarity. The condition has been reported worldwide, with no clear racial or ethnic predilection, although it may be more commonly diagnosed in individuals with darker skin types. Both males and females are affected, with the onset typically occurring in young adulthood.

Prognosis

The prognosis for individuals with DARI is generally good, as the condition is not life-threatening. However, it can cause significant discomfort and psychological distress due to its chronic, recurrent nature and the lack of a definitive cure. With appropriate management, symptoms can be controlled, and the quality of life can be improved.

See Also

• Folliculitis
• Acneiform eruptions
• Skin biopsy

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