Ecto-nox disulfide-thiol exchanger 1
Ecto-nox disulfide-thiol exchanger 1 (also known as ENOX1) is a protein that in humans is encoded by the ENOX1 gene. This protein is a member of the NOX family of NADPH oxidases.
Function[edit | edit source]
ENOX1 is a membrane protein that functions as a disulfide-thiol exchanger. It is involved in the regulation of cell growth and differentiation, and it may also play a role in carcinogenesis.
Structure[edit | edit source]
The ENOX1 protein is a large, multi-domain protein that spans the cell membrane. It contains several cysteine residues that are involved in the formation of disulfide bonds, which are crucial for its function as a disulfide-thiol exchanger.
Clinical significance[edit | edit source]
Mutations in the ENOX1 gene have been associated with a variety of diseases, including cancer, cardiovascular disease, and neurodegenerative disease. In particular, overexpression of ENOX1 has been observed in several types of cancer, suggesting that it may play a role in tumor growth and metastasis.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
