Enallylpropymal

Enallylpropymal is a barbiturate derivative. It has sedative, hypnotic and anticonvulsant properties. Enallylpropymal was formerly used for the treatment of insomnia and other sleep disorders, but it has been replaced by newer drugs with a better safety profile.

History[edit | edit source]

Enallylpropymal was first synthesized in the 1920s. It was used as a sedative and hypnotic drug in the mid-20th century. However, due to the risk of overdose and the development of tolerance and dependence, it has been largely replaced by newer drugs such as benzodiazepines and nonbenzodiazepines.

Pharmacology[edit | edit source]

Enallylpropymal acts by enhancing the action of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, resulting in sedative, hypnotic and anticonvulsant effects. It also inhibits the enzyme cytochrome P450, which may contribute to its drug interactions.

Side effects[edit | edit source]

Side effects of enallylpropymal include drowsiness, dizziness, nausea, vomiting, and respiratory depression. Long-term use can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.

See also[edit | edit source]

Barbiturate
[[GABA_A receptor]]
Cytochrome P450

Enallylpropymal Resources
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