Endotype
An endotype is a subtype of a condition, which is defined by a distinct functional or pathobiological mechanism. This is distinct from a phenotype, which is any observable characteristic or trait of a disease, such as development, biochemical or physiological properties without any implication of a mechanism. It is envisaged that patients with a specific endotype present themselves within phenotypic clusters of diseases. One example is asthma, which is considered to be a syndrome, consisting of a series of endotypes. This is related to the concept of disease entity.
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Contributors: Prab R. Tumpati, MD
