Eric J. Nestler

American neuroscientist

Eric J. Nestler

Eric J. Nestler is an American neuroscientist renowned for his research in the field of neurobiology and psychiatry. He is particularly noted for his work on the molecular mechanisms underlying addiction and depression. Nestler's research has significantly advanced the understanding of how chronic exposure to drugs and stress can lead to long-lasting changes in the brain.

Early life and education

Eric J. Nestler was born in New Haven, Connecticut. He pursued his undergraduate studies at Yale University, where he developed an interest in the biological sciences. Nestler continued his education at Yale School of Medicine, earning both his M.D. and Ph.D. degrees. His doctoral research focused on the molecular pathways involved in neurotransmission.

Career

Nestler began his academic career at Yale University, where he served as a faculty member in the Department of Psychiatry. He later moved to the University of Texas Southwestern Medical Center, where he held the position of Chair of the Department of Psychiatry. In 2008, Nestler joined the Icahn School of Medicine at Mount Sinai as the Dean for Academic and Scientific Affairs and Director of the Friedman Brain Institute.

Research

Nestler's research has primarily focused on the molecular and cellular mechanisms of neuropsychiatric disorders. His work has elucidated the role of transcription factors, such as ΔFosB, in mediating the effects of chronic drug exposure and stress on the brain. Nestler's studies have demonstrated how these factors contribute to the development of addiction and depression by altering gene expression and neural circuitry.

Addiction

In the field of addiction, Nestler's research has provided insights into how repeated exposure to drugs of abuse leads to persistent changes in the brain's reward pathways. His work has identified key molecular players involved in the process of neuroplasticity that underlies addiction, offering potential targets for therapeutic intervention.

Depression

Nestler has also made significant contributions to understanding the pathophysiology of depression. His research has explored how chronic stress affects the brain, leading to depressive behaviors. By studying animal models, Nestler has identified molecular changes that occur in response to stress, which may inform the development of new treatments for depression.

Awards and honors

Eric J. Nestler has received numerous awards for his contributions to neuroscience and psychiatry. He is a member of the National Academy of Medicine and a fellow of the American Academy of Arts and Sciences. His work has been recognized with prestigious awards such as the Pasarow Award in Neuropsychiatry and the NARSAD Distinguished Investigator Award.

Personal life

Nestler is married and has two children. He is an avid supporter of science education and outreach, often engaging in public speaking to promote awareness of mental health issues.

Related pages

• Neuroscience
• Psychiatry
• Addiction
• Depression (mood disorder)