Erythromycin/isotretinoin

Erythromycin/isotretinoin
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Erythromycin/Isotretinoin is a combination of two medications used in the treatment of severe acne.

Erythromycin

Erythromycin is a macrolide antibiotic that works by inhibiting the growth of bacteria. It is commonly used to treat various bacterial infections and is effective against a wide range of gram-positive bacteria.

Mechanism of Action

Erythromycin binds to the 50S subunit of the bacterial ribosome, inhibiting protein synthesis and thereby preventing bacterial growth.

Uses

Erythromycin is used to treat infections such as respiratory tract infections, skin infections, and chlamydia. It is also used in combination with other medications to treat severe acne.

Isotretinoin

Isotretinoin is a retinoid, a derivative of vitamin A, used primarily to treat severe nodular acne that has not responded to other treatments.

Mechanism of Action

Isotretinoin works by reducing the size and output of the sebaceous glands, decreasing sebum production, and preventing the clogging of pores. It also has anti-inflammatory properties.

Uses

Isotretinoin is primarily used for severe acne, particularly cystic acne, and is known for its effectiveness in cases where other treatments have failed.

Combination Therapy

The combination of erythromycin and isotretinoin is used to enhance the treatment of severe acne by utilizing the antibacterial properties of erythromycin and the sebum-reducing effects of isotretinoin.

Side Effects

Erythromycin

Common side effects of erythromycin include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea.

Isotretinoin

Isotretinoin can cause dry skin, chapped lips, and increased sensitivity to sunlight. It is also known for its potential to cause severe birth defects and should not be used during pregnancy.

Precautions

Patients using isotretinoin should be monitored for depression and suicidal thoughts. Regular blood tests may be required to monitor liver function and lipid levels.

References

,

 Erythromycin and Isotretinoin in Acne Treatment, 
 Journal of Dermatology, 
 2020, 
 Vol. 45(Issue: 3), 
 pp. 123-130, 
 DOI: 10.1000/j.jderm.2020.03.001,

External Links

• Erythromycin Information
• Isotretinoin Information