Estradiol hexahydrobenzoate

Estradiol hexahydrobenzoate is a synthetic, steroidal estrogen that is a derivative of estradiol. It is specifically an ester of estradiol with hexahydrobenzoic acid, and is marketed under the brand name Benzo-Ginoestril.

Pharmacology

Estradiol hexahydrobenzoate, like all estrogens, has antigonadotropic effects. It inhibits the secretion of gonadotropins, which in turn suppresses follicular maturation and ovulation. This makes it useful in the treatment of menopausal symptoms and in hormone therapy for transgender women.

Medical uses

Estradiol hexahydrobenzoate is used primarily in hormone replacement therapy (HRT) for menopausal symptoms. It is also used in the treatment of hypogonadism, osteoporosis, and as part of the hormone therapy for transgender women.

Side effects

As with all estrogens, estradiol hexahydrobenzoate can have a number of side effects. These can include nausea, bloating, breast tenderness, and an increased risk of thrombosis. Long-term use can also increase the risk of endometrial cancer.

See also

• Estradiol benzoate
• Estradiol valerate
• Estradiol cypionate

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