Estradiol palmitate

Estradiol Palmitate is a synthetic, steroidal estrogen that is a long-lasting estrogen ester. It is a prodrug of estradiol, and is administered by injection into muscle.

Pharmacology

Estradiol palmitate is a prodrug of estradiol, meaning it is metabolized in the body into estradiol. It is a long-lasting estrogen ester, providing a prolonged duration of effect compared to estradiol itself. This is due to the slow release of estradiol from the ester in the body.

Medical Uses

Estradiol palmitate is used in hormone therapy for menopausal symptoms and low estrogen levels. It is also used in feminizing hormone therapy for transgender women.

Side Effects

Like all estrogens, estradiol palmitate can have a number of side effects, including nausea, bloating, breast tenderness, and an increased risk of blood clots and stroke. It can also cause changes in menstrual periods and mood changes.

History

Estradiol palmitate was first described in the literature in 1953. It has been used in medicine since at least the 1960s.

See Also

• Estradiol
• Estrogen
• Estrogen ester
• Prodrug

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