F2RL3

F2RL3 (also known as Proteinase-activated receptor 4) is a protein that in humans is encoded by the F2RL3 gene. This protein is a member of the protease-activated receptor (PAR) family, which is a subfamily of related G protein-coupled receptors (GPCRs).

Function

F2RL3 is activated by thrombin and trypsin, but not by plasmin or Factor Xa. It is suggested to be involved in platelet activation and regulates angiogenesis in endothelial cells. Thrombin significantly promotes the proliferation and the migration of endothelial cells via the activation of F2RL3.

Clinical significance

Alterations in the F2RL3 gene have been associated with a variety of diseases, including cancer, cardiovascular disease, and inflammation. Methylation of the F2RL3 gene has been proposed as a potential biomarker for lung cancer and cardiovascular disease risk.

Structure

The F2RL3 protein is a seven-transmembrane protein, typical of G protein-coupled receptors. The gene encoding this protein is approximately 12 kb in length and is made up of two exons. The sequence of the intron is highly conserved among different species, suggesting a possible functional significance.

See also

• Protease-activated receptor
• G protein-coupled receptor
• Thrombin
• Trypsin

External links

• F2RL3 at the National Center for Biotechnology Information

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