FOSL1

FOSL1 (FOS Like Antigen 1), also known as FRA1 (Fos-related antigen 1), is a gene that encodes a member of the Fos protein family. The encoded protein is a leucine zipper protein that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOSL1 protein has been implicated in a variety of biological processes, including cell proliferation, differentiation, and transformation, and may also have a role in oncogenesis.

Structure

The FOSL1 gene is located on the long (q) arm of chromosome 11 at position 13. The gene spans approximately 7.6 kilobases and consists of four exons. The encoded protein is composed of 271 amino acids and has a predicted molecular weight of approximately 30 kilodaltons.

Function

FOSL1 is a component of the AP-1 transcription factor complex, which regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. The protein encoded by this gene is thought to regulate cell growth and differentiation and may play a role in cellular senescence.

Clinical significance

Alterations in the expression of FOSL1 have been associated with several types of cancer, including breast cancer, lung cancer, and colorectal cancer. Overexpression of FOSL1 has been shown to promote tumor growth and metastasis, suggesting that it may serve as a potential therapeutic target in cancer treatment.

See also

• AP-1 transcription factor
• Oncogene
• Transcription factor