FOSL2

FOSL2 (FOS Like Antigen 2) is a protein that in humans is encoded by the FOSL2 gene. It is a member of the Fos gene family and is involved in various biological processes, including cell proliferation, differentiation, and transformation.

Function

FOSL2 is a leucine zipper protein that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOSL2 protein has been implicated in a variety of biological processes, including cell proliferation, differentiation, and transformation, and can act as a regulator of the oncogenic transformation.

Clinical significance

Alterations in the FOSL2 gene have been associated with several types of cancer, including lung cancer, breast cancer, and colorectal cancer. In particular, overexpression of FOSL2 has been observed in lung and breast cancer, suggesting a potential role in the development and progression of these diseases.

Research

Research into the role of FOSL2 in cancer has been extensive, with studies investigating its potential as a biomarker for disease progression and as a target for therapeutic intervention. Further research is needed to fully understand the mechanisms by which FOSL2 contributes to cancer development and progression.

See also

• FosB
• c-Fos
• Fos-related antigen 1