FOXA3

FOXA3 (Forkhead Box A3) is a gene that encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.

Function

The FOXA3 gene is a member of the forkhead/winged-helix family of transcription factors. It is very similar in structure and function to three paralogs: FOXA1, FOXA2, and FOXA4. The forkhead family of proteins is characterized by a distinct DNA-binding forkhead domain. The specific function of FOXA3 has not been determined; however, it may play a role in the development of the brain and the gastrointestinal tract.

Clinical significance

Mutations in the FOXA3 gene have been associated with a range of diseases, including type 2 diabetes, obesity, and cancer. Studies have shown that FOXA3 may act as a suppressor of tumor growth in certain types of cancer, including breast cancer and lung cancer.

Research

Research into the FOXA3 gene and its associated proteins is ongoing, with a particular focus on its role in cell differentiation, metabolic regulation, and disease progression.

See also

• Forkhead box protein A1
• Forkhead box protein A2
• Forkhead box protein A4