Fas associated factor family member 2

Fas associated factor family member 2 (also known as FAF2) is a protein that in humans is encoded by the FAF2 gene. The FAF2 protein is a member of the ubiquitin-conjugating enzyme family and is involved in the regulation of apoptosis and autophagy.

Function

FAF2 is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzymes, also known as E2 enzymes, are involved in the process of protein degradation through the ubiquitin-proteasome system. FAF2 has been shown to interact with Fas, a cell surface death receptor involved in the induction of apoptosis.

In addition to its role in apoptosis, FAF2 has also been implicated in the regulation of autophagy, a process by which cells recycle their own components to provide the necessary building blocks for maintaining cellular functions and adapting to stress. FAF2 is thought to regulate autophagy through its interaction with Beclin 1, a key regulator of autophagy.

Clinical significance

Alterations in the FAF2 gene have been associated with various diseases. For example, mutations in FAF2 have been linked to obesity and type 2 diabetes. In addition, FAF2 has been implicated in the development of cancer, with overexpression of FAF2 observed in several types of cancer, including breast cancer and colorectal cancer.

See also

• Ubiquitin-conjugating enzyme
• Fas (cell surface death receptor)
• Beclin 1
• Apoptosis
• Autophagy

References

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