Felty's syndrome

From WikiMD's Wellness Encyclopedia

Swan neck deformity in a 65 year old Rheumatoid Arthritis patient- 2014-05-27 01-49

Felty's syndrome is a rare autoimmune disorder that is characterized by the triad of rheumatoid arthritis, an enlarged spleen (splenomegaly), and a decreased white blood cell count (neutropenia). This condition is considered a severe subset of rheumatoid arthritis and can lead to increased susceptibility to infections.

Signs and Symptoms[edit | edit source]

The primary symptoms of Felty's syndrome include:

  • Rheumatoid arthritis: Chronic inflammation of the joints, leading to pain, swelling, and potential joint deformity.
  • Splenomegaly: Enlargement of the spleen, which can cause discomfort or pain in the upper left abdomen.
  • Neutropenia: A lower than normal count of neutrophils, a type of white blood cell that helps fight infections, leading to increased risk of infections.

Other symptoms may include:

Causes[edit | edit source]

The exact cause of Felty's syndrome is unknown, but it is believed to be related to the autoimmune nature of rheumatoid arthritis. Genetic factors and environmental triggers may also play a role in the development of the syndrome.

Diagnosis[edit | edit source]

Diagnosis of Felty's syndrome typically involves:

  • Clinical evaluation of symptoms
  • Blood tests to check for neutropenia and other abnormalities
  • Imaging studies such as ultrasound or CT scan to assess spleen size
  • Bone marrow biopsy in some cases to rule out other causes of neutropenia

Treatment[edit | edit source]

Treatment for Felty's syndrome focuses on managing the symptoms and underlying rheumatoid arthritis. Common treatments include:

Prognosis[edit | edit source]

The prognosis for individuals with Felty's syndrome varies. With appropriate treatment, many patients can manage their symptoms effectively. However, the condition can lead to serious complications, including recurrent infections and increased risk of lymphoma.

Related Pages[edit | edit source]

References[edit | edit source]

Rheumatologic diseases[edit source]

Arthritis is often used to refer to any disorder that affects the joints. Rheumatic diseases usually affect joints, tendons, ligaments, bones, and muscles. Rheumatologic diseases usually affect joints, tendons, ligaments, bones, and muscles.

Connective Tissue Diseases
Rheumatology and Connective Tissue Diseases
Ankylosing spondylitis Arthritis
Arthritis and Rheumatic diseases Autoimmune diseases
Autoinflammatory diseases Behçet’s disease
Bursitis Giant cell arteritis
Gout Juvenile arthritis
Knee problems Lupus
Osteoarthritis Polymyalgia rheumatica
Psoriatic arthritis Reactive arthritis
Rheumatoid arthritis Scleroderma
Sjögren’s syndrome Systemic lupus erythematosus (Lupus)
Tendinitis Rheumatologic diseases
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Contributors: Prab R. Tumpati, MD