Fibroblastic reticular cell tumor
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Summary[edit | edit source]
- Fibroblastic reticular cell tumor is a very rare dendritic cell tumor affecting the lymph nodes, spleen, and soft tissues.
- Morphologically it is similar to the interdigitating dendritic cell sarcoma or follicular dendritic cell sarcoma.
- The tumor cells are positive for cytokeratin and cd68 with variable clinical outcome.
- Tumors diagnosed as cytokeratin-positive interstitial reticulum cell tumors, probably constitute the same entity.
Signs and Symptoms[edit | edit source]
Signs and symptoms are:
- Generalized papules (single or multiple)
- Painful bone lesion
Diagnosis[edit | edit source]
Diagnosis involves many studies including imaging studies, biopsy for histology, flow cytometry, PET scan, USG
- Blood chemistry studies
- Complete blood count (CBC)
- MRI (magnetic resonance imaging)
- Physical examination and history (H&P)
- Ultrasound exam
Diagnosis[edit | edit source]
Definitive diagnosis requires histologic confirmation and immunophenotyping
Immunophenotyping[edit | edit source]
- The immunophenotyping shows positive for CD68, it is variably immunoreactive
- Other immunophenotyping involves desmin and SMA, which are variably immunoreactive
Treatments[edit | edit source]
ICD codes[edit | edit source]
- ICD-9 Code: 202.9, other and unspecified malignant neoplasms
- ICD-10 Codes:C96.7 other specified malignant neoplasms of lymphoid, hematopoietic
- Corresponding ICD-10-CM Codes (U.S. only): C96.4, sarcoma of dendritic cells (accessory cells) (effective October 01, 2015)
Epidemiology and Mortality[edit | edit source]
- Incidence: very rare
- Survival: limited data is available, spontaneous regression to rapid progression has been seen
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Contributors: Prab R. Tumpati, MD