Fibrofolliculoma
Fibrofolliculoma is a benign skin lesion that is associated with Birt-Hogg-Dubé syndrome. It is characterized by a proliferation of fibrous tissue around a hair follicle.
Clinical Presentation[edit | edit source]
Fibrofolliculomas typically present as small, skin-colored papules on the face, neck, and upper trunk. They are usually asymptomatic, but can sometimes cause cosmetic concern due to their appearance.
Pathogenesis[edit | edit source]
The exact pathogenesis of fibrofolliculomas is not fully understood. However, they are known to be associated with mutations in the Folliculin gene, which is also implicated in Birt-Hogg-Dubé syndrome.
Diagnosis[edit | edit source]
Diagnosis of fibrofolliculomas is typically made based on clinical examination and confirmed with histopathological examination. The characteristic histological feature is a proliferation of fibrous tissue around a hair follicle.
Treatment[edit | edit source]
Treatment of fibrofolliculomas is usually not necessary unless they are causing cosmetic concern. In such cases, they can be removed with surgical excision or laser treatment.
Prognosis[edit | edit source]
The prognosis for fibrofolliculomas is generally good, as they are benign lesions. However, they can be a marker for Birt-Hogg-Dubé syndrome, which can have more serious implications.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD