Fibrofolliculoma

Fibrofolliculoma is a benign skin lesion that is associated with Birt-Hogg-Dubé syndrome. It is characterized by a proliferation of fibrous tissue around a hair follicle.

Clinical Presentation

Fibrofolliculomas typically present as small, skin-colored papules on the face, neck, and upper trunk. They are usually asymptomatic, but can sometimes cause cosmetic concern due to their appearance.

Pathogenesis

The exact pathogenesis of fibrofolliculomas is not fully understood. However, they are known to be associated with mutations in the Folliculin gene, which is also implicated in Birt-Hogg-Dubé syndrome.

Diagnosis

Diagnosis of fibrofolliculomas is typically made based on clinical examination and confirmed with histopathological examination. The characteristic histological feature is a proliferation of fibrous tissue around a hair follicle.

Treatment

Treatment of fibrofolliculomas is usually not necessary unless they are causing cosmetic concern. In such cases, they can be removed with surgical excision or laser treatment.

Prognosis

The prognosis for fibrofolliculomas is generally good, as they are benign lesions. However, they can be a marker for Birt-Hogg-Dubé syndrome, which can have more serious implications.

See Also

• Birt-Hogg-Dubé syndrome
• Folliculin
• Skin lesion

References

Fibrofolliculoma Resources
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