Florence B. Seibert

American biochemist known for her work on tuberculosis testing

Florence Barbara Seibert (October 6, 1897 – August 23, 1991) was an American biochemist best known for her pioneering work in the development of the tuberculin skin test. Her contributions to medical science have had a lasting impact on the diagnosis and treatment of tuberculosis.

Early life and education

Florence Barbara Seibert

Florence Seibert was born in Easton, Pennsylvania, to George Peter Seibert and Barbara (Memmert) Seibert. At the age of three, she contracted polio, which left her with a lifelong limp. Despite this challenge, Seibert excelled academically. She attended Goucher College in Baltimore, where she graduated with a degree in chemistry in 1918. She then pursued graduate studies at the University of Chicago, earning her Ph.D. in biochemistry in 1923.

Career and research

Seibert began her career at the University of Chicago, where she conducted research on the purification of proteins. Her work led to the development of a method to purify tuberculin, the protein used in the Mantoux test for tuberculosis. This method significantly improved the reliability and safety of the test, which became the standard for tuberculosis screening worldwide.

In 1932, Seibert joined the faculty of the University of Pennsylvania, where she continued her research on tuberculosis. Her work was recognized by the American Chemical Society, which awarded her the Garvan-Olin Medal in 1942. Seibert's contributions to medical science were further acknowledged when she was inducted into the National Women's Hall of Fame in 1990.

Later life and legacy

Florence Seibert Historical Marker

After retiring from active research, Seibert continued to be involved in scientific and community activities. She moved to St. Petersburg, Florida, where she lived until her death in 1991. Her legacy is preserved through numerous awards and honors, including a historical marker in her hometown of Easton, Pennsylvania.

Seibert's work laid the foundation for modern tuberculosis testing and has saved countless lives. Her determination and scientific rigor continue to inspire future generations of scientists and medical professionals.

Related pages

• Tuberculosis
• Biochemistry
• Polio
• University of Pennsylvania
• National Women's Hall of Fame