Fluorotabun
Fluorotabun is a chemical compound that belongs to the class of organophosphorus compounds. It is a potent neurotoxin and is considered a chemical weapon. Fluorotabun is structurally related to the well-known nerve gas tabun, but contains a fluorine atom instead of a cyanide group.
History[edit | edit source]
Fluorotabun was first synthesized in the mid-20th century, during the period of intensive research into organophosphorus nerve gases. The exact date and circumstances of its discovery are not well-documented, but it is known that the compound was developed as a potential chemical weapon.
Structure and properties[edit | edit source]
Fluorotabun is an organophosphorus compound, which means it contains a phosphorus atom bonded to carbon atoms. In the case of fluorotabun, the phosphorus atom is also bonded to a fluorine atom, which distinguishes it from other nerve gases such as tabun, which contains a cyanide group instead.
The presence of the fluorine atom in fluorotabun gives it unique properties compared to other nerve gases. Fluorine is highly electronegative, which means it attracts electrons more strongly than most other elements. This results in a polar bond between the phosphorus and fluorine atoms, which can affect the behavior of the molecule in biological systems.
Toxicity and mechanism of action[edit | edit source]
Like other nerve gases, fluorotabun is extremely toxic. It acts by inhibiting the enzyme acetylcholinesterase, which is responsible for breaking down the neurotransmitter acetylcholine in the nervous system. When acetylcholinesterase is inhibited, acetylcholine accumulates in the synapses, leading to overstimulation of the nerves and potentially fatal effects.
The symptoms of fluorotabun poisoning are similar to those of other nerve gases and include difficulty breathing, convulsions, and loss of consciousness. Treatment involves the administration of antidotes that can reactivate acetylcholinesterase, as well as supportive measures to manage the symptoms.
Legal status[edit | edit source]
The production, possession, and use of fluorotabun are prohibited by the Chemical Weapons Convention, which classifies it as a Schedule 1 substance. This means it is considered to have no legitimate uses outside of research, medical, or pharmaceutical purposes.
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Contributors: Prab R. Tumpati, MD