Fosmanogepix
Fosmanogepix is an antifungal drug that is currently under development. It is a first-in-class agent that works by inhibiting the enzyme Gwt1, which is essential for the growth and survival of fungi. Fosmanogepix has shown promise in treating a wide range of fungal infections, including those caused by Candida, Aspergillus, and rare molds.
Mechanism of Action[edit | edit source]
Fosmanogepix works by inhibiting the enzyme Gwt1. This enzyme is involved in the synthesis of glycosylphosphatidylinositol (GPI), which is a component of the fungal cell wall. By inhibiting Gwt1, fosmanogepix disrupts the integrity of the fungal cell wall, leading to cell death.
Clinical Trials[edit | edit source]
Fosmanogepix is currently in Phase 2 clinical trials for the treatment of invasive fungal infections. Preliminary results have shown that it is well-tolerated and effective against a broad range of fungal pathogens, including drug-resistant strains.
Potential Applications[edit | edit source]
If approved, fosmanogepix could be used to treat a variety of fungal infections, including invasive candidiasis, aspergillosis, and rare mold infections. It could also be a valuable treatment option for patients with immunocompromised conditions, who are at increased risk of developing serious fungal infections.
See Also[edit | edit source]
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